Are there more than 2 genders or sexes?

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Men who transition to being women tend to have a similar brain structure to women who were born biologically female.

The bed nucleus of the stria terminalus (BSTc) and the sexually dimorphic nucleus of trans women are more similar to those of cisgender woman than to those of cisgender men—suggesting that the general brain structure of these women is in keeping with their gender identity..

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Sexual dimorphism (differences of physical characteristics between sexes) isn't proof there are only two sexes or genders.

For some properties in which differences between sexes are observed—like brain volume and connectivity—trans people possessed values in between those typical of cisgender males and females, both before and after transitioning.

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A significant amount of scientific research has shown that gender (even in intersex people) is the result of prenatal hormone exposure.

Girls with congenital adrenal hyperplasia (CAH)—which leads to their masculinisation—are more likely to play with male-typical toys. Although parents encourage sex-typical behavior, their encouragement appears to be insufficient to override the interests of girls with CAH.

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A 2017 study analysing toy preferences in children suggests gender is heavily biological, not just a result of social pressures.

The review found that boys are more likely to play with "male toys" and girls with "female toys", due to biological drivers. The size of sex differences in children’s preferences for male-typed and female-typed toys was not smaller in studies done in more egalitarian societies.

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